Moynihan Mycobacteriology Group


We study how mycobacteria build, maintain, and deploy their complex cell envelopes — from capsule polysaccharides to secretion systems — to understand Mycobacterium tuberculosis pathogenesis and discover new vulnerabilities.

Department of Microbiology & Immunology · Schulich School of Medicine & Dentistry · Western University

Research

Capsule Biology

Capsule deposition kinetics, polysaccharide export across the mycomembrane, and how capsule composition shapes host immune recognition.

Cell Envelope Biochemistry

Enzymes that build and remodel the tripartite peptidoglycan–arabinogalactan–mycolic acid cell wall, including arabinomannan release by LamH.

Glycoside Hydrolases

New CAZyme families (GH172, GH183) that degrade mycobacterial polysaccharides, including weaponised variants for interbacterial competition.

T7SS & Competition

Type VII secretion-mediated toxin delivery enabling inter-mycobacterial antagonism across the Mycobacteriales.

Predatory Bacteria

Bacterial predation as a driver of cell envelope evolution — how predatory organisms target and lyse mycobacterial prey and what this reveals about envelope vulnerabilities.

Diagnostics

Enzyme-based diagnostic tools that exploit the unique carbohydrate structures of the mycobacterial cell envelope for rapid and specific detection of mycobacterial infections.

Funding

NSERC Canada Research Chairs CFI Wellcome Trust Gates Foundation BBSRC